Broadcast in May 2011 this webinar was co-sponsored by the APHL Quality Assurance/Quality Control Subcommittee of the Newborn Screening and Genetics in Public Health Committee and the CDC Newborn Screening Quality Assurance.
Designed to examine the clinical background of SCID, use of the TREC assay and implementation of SCID in four newborn screening programs. This webinar series was recorded in two 90-minute sessions.
The workshop topics are listed below and those presentations with links have been authorized to be posted on this Web site. Duplication is not authorized without the express written permission of the authors.
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Moderator, Ken Pass, PhDT-Cell Related Immunodeficiency DisordersLisa Kobrynski, MD, MPH, Emory University
Dr. Kobrynski provided an overview of SCID that focused on clinical manifestations as well as the diagnosis and treatment. Her presentation also included a review of other T cell lymphopenias that may be detected through newborn screening for SCID.
Overview of SCID TestingCarla, Cuthbert, PhD, FACMG, FCCMG, CDC Newborn Screening and Molecular BiologyDr. Cuthbert discussed potential markers for SCID detection on newborn screening dried blood spots, including T-Cell Receptor Excision Circles (TREC) and other potential protein markers. She also discussed the Centers for Disease Control's (CDC's) role in implementing SCID testing which entailed assay development, quality control, and proficiency testing.
Recorded webinar linked here.
Overview of Testing AlgorithmsBob Vogt, PhD, CDC Newborn Screening and Molecular Biology Branch
Dr. Vogt presented an overview of the current SCID testing methods used in newborn screening. The focus was on equipment, assay standardization and validation, routine quality assurance and control activities, cost considerations, and pilot proficiency testing activities at the CDC.
SCID Screening Program Summaries - SCID Laboratory Testing Experience
Four state screening programs provided an overview of their SCID screening experience including the history of testing, reporting algorithms, screening results, and unique experiences.
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Senior Specialist, Newborn Screening & Genetics
Association of Public Health Laboratories
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