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Conference Proceedings

2010 Newborn Screening and Genetics Testing Symposium
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The 2010 Newborn Screening and Genetic Testing Symposium was held in Orlando, FL from May 3-6, 2010 and brought together almost 400 laboratorians, follow-up professionals and metabolic specialists from around the world. Participants came from all 47 states and 19 countries. It produced varied and expansive discussion on many aspects of newborn screening. The symposium also featured two pre-conference sessions on Second Tier Testing for Newborn Screening and Short-term and Long-term Follow-up. Sessions during the meeting included topics on Health Information Technology, Education, Quality Improvement: Program, Quality Improvement: Laboratory, International Perspectives, Old Conditions, New Information, Candidate Conditions.

Slide Presentations

The symposium schedule is listed below and those presentations with links have been authorized to be posted on this Web site. Duplication is not authorized without the express written permission of the authors. The author and “2010 NBS&GTS” must be cited once permission is received.

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Monday, May 3, 2010

           Pre-Conference Session - Quality Assurance/Quality Control Workshop

          Second Tier Testing for Newborn Screening - Enhancements for  Performance            Metrics
          Moderator - Kenneth Pass, Wadsworth Center Gary Hoffman,     
                                Wisconsin State Laboratory of Hygiene

          What is a Second Tier Test?
           - Kenneth Pass, Wadworth Center

           Primary Congenital Hypothyroidism-T4/TSH vs. TSH Only
           - Patrick Hopkins, Missouri Public Health Laboratory

           Second Tier Testing for CAH Testing-The California Experience
          - Fred Lorey, California Department of Public Health

           Second Tier Testing for Metabolic Disorders: A Regional Approach
          - Marzia Pasquali, ARUP Laboratories

           Cystic Fibrosis and Galactosemia: Two Conditions and Two Models for Use of DNA
           Markers in the Second Tier of Screening
          - Anne Comeau, New England Newborn Screening Program

           Second Tier Molecular Testing in the Texas Newborn Screening Program
          - Rachel Lee, Texas Department of State Health Services

           Development of a Second Tier GC-MS Screening Assay for Organic Acidemias Using
           Newborn Screening Dried Blood Spots

          - James Lim, Kentucky Department of Public Health

          Monitoring PKU and MSUD in One Method from Dried Blood Spots Using LC/MS/MS
          - Chunli Yu, Mount Sinai School of Medicine

          Is Second Tier Screening for CAH Cost Effective? The Influence of State Laboratory
          Testing and Follow-up Practices

          - Scott Grosse, Centers for Disease Control and Prevention

          Pre-Conference Session - Short-term and Long-term Follow-up

          Newborn Screening in the NICU/SCBU: Protecting Our Smallest Infants
          Moderator - Judi Tuerck, Northwest Regional Newborn Screening Program

          The Day in the Life of a Pre-term Infant
          - Christine J. Valentine, Nationwide Children’s Hospital and the Ohio State University

          CLSI-I/LA31-A: Newborn Screening for Premature and/or Sick Newborns: Approved
          Guidelines

          - Julie Miller, Nebraska Department of Health & Human Service

          Serial Screening of NICU/SCBU Infants – Not as Overwhelming as One Might Think:
          NW Regional Newborn Screening Program’s Experience

          - Leanne Rien, Oregon State Public Health Laboratory

         Serial Screening of NICU/SCBU Infants – Developing a Three-Part Newborn Screening
         Kit

          - Leanne Rien, Oregon State Public Health Laboratory

          Friendly Feud – Interactive Session

          Long-term Follow-up
          Moderator - Lois Taylor, Florida Department of Health and Lanetta Jordan, 
                                Memorial Regional Hospital

         Retrieval and Short-term Follow-up Feedback Mechanisms in Ontario, Canada
          - Jennifer Milburn, Ontario Newborn Screening Program

         Enhancing Current Surveillance Systems to Capture Long-Term Outcomes For
         Confirmed Newborn Screening Cases: Preliminary Results from a Four-State Pilot
         Project

          - Cynthia Hinton, Centers for Disease Control & Prevention

         Development of a Population-based Surveillance and Tracking System in New York
         State for Long-term Follow-up of Children Identified Through Newborn Screening

          - Ying Wang, New York State Department of Health

         Development of Nutrition Guidelines for Inborn Errors of Metabolism Detected by
         MS/MS NBS: An Important Component of Long-term Follow-up
          - Dianne Frazier, University of North Carolina

         Opening Keynote

         - Jim Kelly, Hunter’s Hope Foundation

        Newborn Screening Molecular Testing Forum 

        Enhancing Newborn Screening Through Molecular Testing
          - Suzanne Kehoe Cordovado, Centers for Disease Control & Prevention

        Advances and Gaps in Newborn Screeing Molecular Testing
          - Michele Caggana, New York State Department of Health, Wadsworth Center

        Looking Towards the Future of Expanded Molecular Testing in Newborn Screening
          - Christopher N. Greene, Centers for Disease Control & Prevention

        Quality Assurance Program for Molecular Screening
          - Marie Earley, Centers for Disease Control & Prevention

        Newborn Screening Molecular Network: A Synergistic Partnership
          - Suzanne Kehoe Cordovado, Centers for Disease Control & Prevention 

 

Tuesday, May 4, 2010 

         Roundtables

         Newborn Screening Follow-up and Tracking: Overarching Questions
          - Colleen Boyle, Centers for Disease Control and Prevention

         IRT/IRT/DNA Methodology for Cystic Fibrosis Newborn Screening
          - Susan Tanksley, Texas Department of State Health Services

         Session 1 - Health Information Technology(HIT)
          Moderator - Mark McCann, Minnesota Department of Health, Public Health Laboratory and
                                Brad Therrell, Mational Newborn Screening and Genetics Resource center

          Newborn Screening, the Health Information Technology Act and Health Information
          Exchange
          - Alan Hinman, Task Force for Global Health

         Adapting the HL7 v2.5.1 Lab Result Message to Carry Newborn Screening Results
          - Rebecca Goodwin, National Library of Medicine

         Electronic Ordering of Newborn Screening and the Role of Electronic Newborn
         Discharge Summary in Delivering NBS Results to Primary Care Providers

          - Alan Zuckerman, National Library of Medicine

         Implementing Health Information Technology Standards in Pennsylvania’s Newborn
        Screening Program

          - Carolyn Ellison, Pennsylvania Department of Health and Roger Eaton, New England
            Newborn Screening Program

          Session 2 - Education
          Moderator - Julie Miller, Nebraska Department of Health & Human Services and Natasha
                                Bonhomme, Genetic Alliance

          Training of Nurses Regarding the New Updated CLSI Guidelines for Preterm, Low Birth
           Weight and Sick Infants
          - Becky Whittemore, Oregon State Public Health Laboratory

          Mother’s Experiences with Education about Newborn Screening in Ontario: Implication
          for Practice

          - Kim Gall, Ontario Newborn Screening Program

          Geographical Differences in Pediatricians’ Knowledge of Newborn Screening and
          Management of Hemoglobinopathies

          - Kirsty McWalter, Hawaii Department of Health Genetics Program

          Educational DVD for Parents and Providers on CPT-1 Deficiency
          - Thalia Wood, Alaska Department of Health and Social Service

          Newborn Screening Wisdom for the Ages: Lessons Learned and Roads Already
          Traveled

          Moderator - Julie Miller, Nebraska Department of Health & Human Services
          Panelists – George Cunningham, Harry Hannon, Kenneth Pass, Judi Tuerck and Bridget
                                Wilcken

          Session 3Quality Improvement: Program
          Moderator - J. Gerard Loeber, National Institute Public Health (RIVM), The Netherlands
                               and Michele Lloyd-Puryear, Health Resources and Services Administration

         Texas Newborn Screening Performance Measures Project
          - Susan Tanksley, Texas Department of State Health Services

         Regional Newborn Screening Harmonization Through Quality Improvement
          - Barb Schweitzer, North Dakota Department of Health, Kim Turner, University of Iowa
            Hospitals and Clinics and Carol Johnson, University of Iowa Hygienic Labortory

         Quality Improvement of Short-term Follow-up for Newborn Screening Performed by an
         Out-of-State Regional Laboratory
          - Arthur Yu, Hawaii Department of Health Genetics Program

         Ascertainment of Cystic Fibrosis Cases with False-Negative Newborn Screening
         Results
          - John Thompson, Washington State Department of Health

        Session 4 - Quality Improvement: Laboratory
          Moderator - Gary Hoffman, Wisconsin State Laboratory of Hygiene and Carla Cuthbert,
                                Centers for Disease Control & Prevention

         Upcoming Recommendations for Good Laboratory Practices for Biochemical Genetic
         Testing and Newborn Screening for Inherited Metabolic Disorders

          - Bin Chen, Centers for Disease Control & Prevention

         Screening Test Results on Overspotted Filter Papers
          - Dennis Freer, PerkinElmer Genetics, Inc.

         Proficiency Testing Results for Low Free Carnitine and Hydroxyisovalerylcarnitine by
         Tandem Mass Spectrometry: Impact of Laboratory Cutoff Practices

          - Victor De Jesus, Centers for Disease Control & Prevention

         Enlarging National Newborn Screening Back-up Capacity by Establishing a Network of
         Harmonized Newborn Screening Laboratories

          - Stanton Berberich, University of Iowa Hygienic Laboratory

 

Wednesday, May 5, 2010

         Roundtables

         Harmonization in Testing Unsatisfactory Newborn Screening Specimens
          - Patrick Hopkins, Missouri Public Health Laboratory and Joseph Orsini, New York State
            Department of Health

         Improving the Image of Newborn Screening 
          - Susan Tanksley, Texas Department of State Health Services and Natasha Bonhonme,
            Genetic Alliance  

         Session 5International Perspectives
          Moderator - Kenneth Pass, Wadsworth Center and Max Salfinger, Florida Department of
                                Health

         Expanded Newborn Screening by Tandem Mass Spectrometry in Germany, Austria and
         Switzerland: Different Rationales for the Selection of Target Disorders in Comparison
         to the ACMG Panel

          - Zoltan Lukacs, University of Hamburg, Germany

         Diagnosis of Low Excretor GA1 by Measuring 3-Hydroxyglutaric Acid in Dried Urine
         Spots

          - Osama Y. Al-Dirbashi, Ontario Newborn Screening Program, Canada

         Cystic Fibrosis Screening in the Netherlands to Go Ahead
          - J. Gerard Loeber, National Institute Public Health (RIVM), The Netherlands

         Screening for Duchenne Muscular Dystrophy
          - Francois Eyskens, PCMA, Belgium

         Session 6Old Conditions, New Information
          Moderator - Cheryl Hermerath, Oregon State Public Health Laboratory and Stuart Shapira,
                                Centers for Disease Control & Prevention

         Rising Incidence of Congenital Hypothyroidism in Massachusetts
          - Inderneel Sahai, New England Newborn Screening Program

         Ten Year Review of CAH Cases in Washington State Newborn Screening
          - Caroline Nucup-Villaruz, Washington State Department of Health

         Comparison of Two Newborn Screening Systems for Hemoglobinopathy Identification
          - Christine McKeever, Tennessee Department of Health

         Sickle Cell Trait Carrier Status Screening – A Report to the Secretary’s Advisory
         Committee on Heritable Disorders in Newborns and Children

          - Melissa Creary, Centers for Disease Control & Prevention
          - Lenee Simon, Health Resources and Services Administration

         Session 7 Candidate Conditions – Severe Combined Immunodeficiency (SCID)
          Moderator - Susan Tanksley, Texas Department of State Health Services and Denise
                                Higgins, Montana Public Health Laboratory

         Newborn Screening for Severe Combined Immunodeficiency in Wisconsin
          - Mei Baker, Wisconsin State Laboratory of Hygiene

         Implementation of a SCID NBS Program Using a Multiplex Assay and an Integrated
         Program Approach: Massachusetts Technical and Program Experience

          - Anne Comeau, New England Newborn Screening Program

         SCID Detection in the Guthrie Specimen by Immunoassay
          - David Janik, Wadsworth Center

         Development of Reference Materials for Calibration of Quantitative Real-time PCR
         Assays Used to Quantify T-cell Receptor Excision Circles in Dried Blood Spots

          - Robert Vogt, Centers for Disease Control & Prevention

         Session 8 Candidate Conditions – Lysosomal Storage Disorders (LSD)
          Moderator - Robert Vogt, Centers for Disease Control & Prevention and Patrick Hopkins,
                                Missouri Public Health Laboratory

         Advances in Screening for Lysosomal Storage Disorders by MS/MS
          - Ron Scott, University of Washington

         Automation of Multiplexed Tandem Mass Spectrometry Methods for Screening of
         Newborns for Lysosomal Storage Disorders: Pilot Study and Practical Limitations and
         Observations

          - Joseph Orsini, New York State Department of Health

         Laboratory Support at the CDC for Newborn Bloodspot Screening of Lysosomal
        Storage Disorders

          - Hui Zhou, Centers for Disease Control & Prevention

         Digital Microfluidic Platform for Multiplexing LSD Assays in Newborn Screening
          - David Millington, Duke University

           

Thursday, May 6, 2010

         Session 9Financial, Ethical, Legal and Social Implications (FELSI)
          Moderator - Joanne Mei, Centers for Disease Control & Prevention and Fred Lorey,
                                California Department of Public Health

         Michigan BioTrust for Health: Community Engagement Methods and Results
          - Carrie Langbo, Michigan Department of Community Health

         Parents are Asking “What is the Government Doing with my Baby’s DNA?” -
         Washington State’s Experience with Residual Newborn Screening Blood Spots
          - Sheila Weiss, Washington State Department of Healthy

          National Policy Regarding:
          The Retention and Use of Residual Dried Blood Spot Specimens after Newborn 
         
Screening Carrier Screening: Whom to Test? When to Test?

           - R. Rodney Howell, Chair, Secretary"s Advisory Committee on Heritable Disorders in
             Newborns and Children

         Session 10Clinical Outcomes
          Moderator - Harry Hannon, Centers for Disease Control & Prevention and Sue Berry,
                               University of Minnesota

         Gestational Age, Birthweight and Month at Collection Impact Analytes Collected for
         Newborn Screening

          - Kelli Ryckman, University of Iowa

         Mandated Coverage of Metabolic Foods and Formulas: A Decade of Experience
          - Sarah Scollon, Hawaii Department of Health Genetics Program

         Parent Survey of Insurance Coverage of Medical Foods for Children with Metabolic
         Conditions

          - Mary Kay Kenney, Health Resources and Services Administration

         The Newborn Screening Translational Research Network (NBSTRN): An NICHD/NIH
         Initiative

          - Amy Hoffman, American College of Medical Genetics

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