Page Content Molecular screening brings new and different technologies into the newborn screening (NBS) laboratory, creating a need for related resources. APHL collaborates with CDC's Newborn Screening and Molecular Biology Branch (NSMBB) to provide state newborn screening programs with information on available molecular methods and quality improvement activities. NBS Molecular Methods State NBS Lab Assays The state NBS laboratory assays list (access restricted to NBS lab directors and their delegates) explains how newborn screening programs use their molecular assays and allows users to search for the molecular assay that best fits their needs. Sequencing Decision Matrix The NBS sequencing decision matrix helps NBS programs evaluate considerations on incorporating gene sequencing into their program. The matrix tool outlines various factors involved in getting your program ready for sequencing and incorporates skip logic to generate custom recommendations for future applications of sequencing. Automation Methods The links below offer information on the use of automation in newborn screening programs, types of automation instruments and considerations in purchasing a liquid handler: Liquid Handling Instruments Automation Methods (access restricted to NBS lab directors and their delegates) Considerations in Selecting a Liquid Handler Liquid Pipetting Verification (access restricted to NBS lab directors and their delegates) Molecular Assessment Program Quality Improvement The Molecular Assessment Program (MAP) is a non-regulatory site visit offered by CDC and APHL that is tailored to newborn screening laboratories that perform molecular tests. MAP was developed to assist newborn screening laboratories to determine how to best meet their molecular testing needs with available resources. View more information on testimonials, checklists and to rate your MAP visit. Molecular Training ResourcesWebinarsUse of Molecular Methods in Hemoglobinopathies Screening: State Experiences (2023)Use of Molecular Methods in Hemoglobinopathies Screening: The Clinician Perspective (2023)Molecular Training WorkshopAPHL Molecular Training Workshop (2020)Gene Sequencing ResourcesGene Sequencing Forum at NBS Symposium (2017)Gene Sequencing in Public Health Newborn Screening Meeting (2017)APHL Next Generation Sequencing Implementation Guide (2017) Frequently Asked Questions Spinal Muscular Atrophy Organizing and Optimizing Laboratory Space for Molecular Workflow Contact For more information about these molecular resources or if you need assistance accessing content, please contact APHL Newborn Screening & Genetics Program. It looks like your browser does not have JavaScript enabled. Please turn on JavaScript and try again.