Molecular screening brings new and different technologies into the newborn screening (NBS) laboratory, creating a need for related resources. APHL collaborates with CDC's
Newborn Screening and Molecular Biology Branch (NSMBB) to provide state newborn screening programs with information on available molecular methods and quality improvement activities.
NBS Molecular Methods
State NBS Lab Assays
The
state NBS laboratory assays list (access restricted to NBS lab directors and their delegates) explains how newborn screening programs use their molecular assays and allows users to search for the molecular assay that best fits their needs.
Sequencing Decision Matrix
The
NBS sequencing decision matrix helps NBS programs evaluate considerations on incorporating gene sequencing into their program. The matrix tool outlines various factors involved in getting your program ready for sequencing and incorporates skip logic to generate custom recommendations for future applications of sequencing.
Automation Methods
The links below offer information on the use of automation in newborn screening programs, types of automation instruments and considerations in purchasing a liquid handler:
Molecular Assessment Program Quality Improvement
The Molecular Assessment Program (MAP) is a non-regulatory site visit offered by CDC and APHL that is tailored to newborn screening laboratories that perform molecular tests. MAP was developed to assist newborn screening laboratories to determine how to best meet their molecular testing needs with available resources.