Molecular screening brings new and different technologies into the newborn screening ​(NBS) laboratory, creating a need for related resou​rces. APHL collaborates with CDC's Newborn Screening and Molecular Biology Branch (NSMBB)​ to provide state newborn screening programs with information ​on available molecular methods and quality improvement activities.​

​NBS Molecular Methods

Sequencing Decision Matrix

The NBS sequencing decision matrix helps NBS programs evaluate considerations on incorporating gene sequencing into their program. The matrix tool outlines various factors involved in getting your program ready for sequencing and incorporates skip logic to generate custom recommendations for future applications of sequencing.

Molecular Assessme​nt Program Quality Improvement 

The Molecular Assessment Program (MAP) is a non-regulatory site visit offered by CDC and APHL that is tailored to newborn screening laboratories that perform molecular tests. MAP was developed to assist newborn screening laboratories to determine how to best meet their molecular testing ne​eds with available resources. 

View more information on testimonials, checklists and to rate your MAP visit.

Molecular Training Resources​

Webinars

Use of Molecular Methods in Hemoglobinopathies Screening: State Experiences (2023)

Use of Molecular Methods in Hemoglobinopathies Screening: The Clinician Perspective (2023)

Molecular Training Workshop

APHL Newborn Screening Molecular Training Workshop 

Frequently Asked Questions

Organizing and Optimizing Laboratory Space for Molecular Workflow​

Contact 

For more information about these molecular resources or if you need assistance accessing content, please contact APHL Newborn Screening & Genetics Program