APHL collaborates with CDC to assure proficiency and quality of newborn screening test results at state public health laboratories, through emergency coordination, policy guidance and improvements to information exchange processes.

In partnership with APHL, CDC's Newborn Screening Molecular Biology Branch (NSMBB) operates a voluntary, non-regulatory program to maintain and enhance the quality of newborn test results at state public health laboratories. The Newborn Screening Quality Assurance Program (NSQAP) provides services to more than 88 domestic newborn screening laboratories, 31 manufacturers of diagnostic products and laboratories in 85 countries. It has served as the reputable source for newborn screening quality assurance services for over 41 years.

​The NSQAP sends coded specimens to participating laboratories to assess their testing proficiency. If a laboratory makes an error in identification, the program works with the institution to identify the error and improve laboratory practices. The program also publishes quarterly reports to allow laboratories to benchmark practices against their peers.

Newborn Screening Analyte Interference List

The Newborn Screening Analyte Interference List is a compilation of published and observed analyte interferences of newborn screening assays. The list serves as a central, one-stop resource for all known newborn screening assay interferences. Users can both review and add interferences to the list. 

Cutoff Determinations and Risk Assessment Methods 

The Overview of Cutoff Determinations and Risk Assessment Methods used in Dried Blood Spot Newborn Screening - Role of Cutoffs and Other Methods of Data Analysis​​ provides a general overview of the variety of approaches utilized by newborn screening laboratories and program staff to determine if a newborn is at risk for a screened disorder. ​

Quality Control/Quality Assurance Training Materials

2018 Spinal Muscular Atrophy (SMA) Webinar Series

Clinical Aspects, Diagnostics and Follow-Up Recording and Transcript

Overview of Available Screening Methods Recording  and Transcript

2017 Mucopolysaccharidosis type I (MPS I) Webinar Series

Implementation Considerations Webinar Recording and Transcript

Clinical Aspects Webinar Recording and Transcript

Overview of Available Screening Methods Webinar Recording and Transcript

Other QA/QC Webinars

2016 APHL X-linked adrenoleukodystrophy (X-ALD) 101- Clinical Aspects and Screening Methods Webinar Recording and Transcript

2014 APHL Pompe Disease 101 - Clinical Aspects and Screening Methods Webinar