​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​CDC’s Advanced Molecular Detection (AMD) initiative aims to improve the identification and characterization of infectious diseases by increasing critical next generation sequencing (NGS) and bioinformatics capacities at CDC and at state and local health departments.

Since 2013, APHL h​as worked with CDC and other partners to characterize current NGS capability and capacity, develop a strong AMD workforce and deploy NGS technologies to public health laboratories. 

AMD Virtual​

​AMD Day is a two-day event to promote information sharing among public health scientists working in AMD and to showcase their accomplishments to CDC leadership. Held on the CDC campus in Atlanta, AMD Day brings together laboratory scientists, bioinformatics experts, and infectious disease epidemiologists to meet and discuss their successes, challenges, and future plans for the transformation of public health practice through AMD. 

In lieu of our in-person meeting, CDC and APHL are holding AMD Vi​​rtual​, which is monthly sessions around the use of Next Generation Sequencing technology in public health. Each month we will look at a different topic related to the use of AMD technology in public health laboratories. Monthly sessions will continue through April. 

Building the AMD Workforce

Bioinformatics ​​​Fellowship

APHL has administered the APHL-CDC Bioinformatics Fellowship since its launch in 2013. The fellowship aims to train and prepare bioinformaticians to apply their expertise within public health and to design tools that will aid existing public health personnel in the use of bioinformatics.

Building Bioinformatics with Academic Institutions​​

The increase in public health applications of next-generation sequencing (NGS) has created new challenges, including additional demands for bioinformatics computing power. One potential solution is to build bioinformatics capabilities in a public health laboratory through partnerships with academic institutions. Partnerships for sharing sequencing resources and specimen collections can improve both the capacity and ​efficiency of Public Health Laboratories.


APHL has created a webinar series that is available for free to state and local health department staff. Continuing education credits are available.

  1. Understanding NG​S Instrumentation and IT Requirements

  2. Communication Strategies for Laboratorians and Epidemiologists on NGS Data​​​

Deploying Technology

APHL works closely with CDC and public health laboratories to build AMD capacity to improve the detection and surveillance of particular pathogens. Through the organization of training opportunities, facilitation of technical assistance and management of proficiency checks, APHL has assisted with the transfer of AMD technologies in several key program areas.​

More Information About AMD

CDC Advanced Molecular Detection ​