​​​CDC’s Advanced Molecular Detection (AMD) initiative aims to improve the identification and characterization of infectious diseases by increasing critical next generation sequencing (NGS) and bioinformatics capacities at CDC and at state and local health departments.

Since 2013, APHL has worked with CDC and other partners to characterize current NGS capability and capacity, develop a strong AMD workforce and deploy NGS technologies to public health laboratories. Review the CDC/APHL Advanced Molecular Detection Strategic Map, 2015-2017.

Characterizing Capacity

APHL regularly surveys public health laboratories to identify improvements in AMD capabilities, pinpoint areas that still need improvement and identify mitigation strategies.    

Building the AMD Workforce

Bioinformatics ​​​Fellowship

APHL has administered the APHL-CDC Bioinformatics Fellowship since its launch in 2013. The fellowship aims to train and prepare bioinformaticians to apply their expertise within public health and to design tools that will aid existing public health personnel in the use of bioinformatics.


APHL has created a webinar series that is available for free to state and local health department staff. Continuing education credits are available.

  1. An Overview of CDC’s Advanced Molecular Detection Initiative

  2. Bioinformatics in Public Health Laboratories

  3. Whole Genome Sequencing of Bacterial Pathogens

  4. Next-generation Sequencing and Viral Pathogens

  5. Update on CDC’s Advanced Molecular Detection Initiative

  6. Understanding NGS Instrumentation and IT Requirements

  7. Use of Whole Genome Sequencing in Legionnaires' Disease Outbreak in Minnesota

  8. Use of Next Generation Sequencing technology in Influenza Surveillance

  9. Using the NCBI Pathogen Detection portal fo​​r surveillance

  10. Experiences of a Bioinformatics Fellow, Cohort 2018-2019

Deploying Technology

APHL works closely with CDC and public health laboratories to build AMD capacity to improve the detection and surveillance of particular pathogens. Through the organization of training opportunities, facilitation of technical assistance and management of proficiency checks, APHL has assisted with the transfer of AMD technologies in several key program areas.​

​​​AMD Day

​AMD Day is a two-day event to promote information sharing among public health scientists working in AMD and to showcase their accomplishments to CDC leadership. Held on the CDC campus in Atlanta, AMD Day brings together laboratory scientists, bioinformatics experts, and infectious disease epidemiologists to meet and discuss their successes, challenges, and future plans for the transformation of public health practice through AMD. In 2017, the two-day event included speakers, workshops, a panel discussion, rapid-fire poster overviews, poster viewing sessions, AMD IGNITE storytelling session, and awards for the Art of AMD data visualization contest.

More Information About AMD

CDC Advanced Molecular Detection ​